Amyloid pathology and axonal injury after brain trauma
نویسندگان
چکیده
منابع مشابه
Amyloid pathology and axonal injury after brain trauma
OBJECTIVE To image β-amyloid (Aβ) plaque burden in long-term survivors of traumatic brain injury (TBI), test whether traumatic axonal injury and Aβ are correlated, and compare the spatial distribution of Aβ to Alzheimer disease (AD). METHODS Patients 11 months to 17 years after moderate-severe TBI underwent (11)C-Pittsburgh compound B ((11)C-PiB)-PET, structural and diffusion MRI, and neurops...
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conclusions a long-term longitudinal study encompassing integrated research is needed to fully understand the traumatic experiences of caregivers. unless research on tbi or dai trauma is given its proper attention, the burden of trauma and injury on societies will continue to exacerbate globally. context as with care giving and rehabilitation in chronic illnesses, the concern with traumatic bra...
متن کاملWidespread Tau and Amyloid-Beta Pathology Many Years After a Single Traumatic Brain Injury in Humans
While a history of a single traumatic brain injury (TBI) is associated with the later development of syndromes of cognitive impairment such as Alzheimer’s disease, the long-term pathology evolving after single TBI is poorly understood. However, a progressive tauopathy, chronic traumatic encephalopathy, is described in selected cohorts with a history of repetitive concussive/mild head injury. He...
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Severe traumatic brain injury (TBI), defined as patients with a Glasgow Coma Scale (GCS) score ≤ 8, is a well-known cause of life-long disability and death. TBI is commonly observed in young adults although the incidence of elderly people is increasing. TBI has also been identified as an important environmental risk factor for the development of Alzheimer ́s disease (AD) later in life. Amyloid-β...
متن کاملDiffuse Axonal Injury in Head Trauma
Background: Diffuse axonal injury (DAI) is one of the most common and important pathologic features of traumatic brain injury (TBI). The susceptibility of axons to mechanical injury appears to be due to both their viscoelastic properties and their high organization in white matter tracts. Although axons are supple under normal conditions, they become brittle when exposed to rapid deformations a...
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ژورنال
عنوان ژورنال: Neurology
سال: 2016
ISSN: 0028-3878,1526-632X
DOI: 10.1212/wnl.0000000000002413